1. Introduction
Magnetic resonance imaging (MRI) of the breast
was first performed in the late 1980s. At first, differentiation between benign
and malignant breast lesions was primarily based on their differences in T1 and
T2 relaxations times (Rausch et al., 2006). Due to the large overlap in T1 and
T2 relaxation times in benign and malignant breast lesions, it became apparent
that contrast administration was mandatory for reliable breast MRI. Heywang et
al. demonstrated that breast carcinomas showed significant enhancement within 5
minutes after contrast administration (Heywang et al., 1989).
Since then, increasing field strengths,
dedicated breast coil designs, and
improvements in sequence protocols have led to a large improvement in
diagnostic accuracy of breast MRI. Currently, the sensitivity of
contrast-enhanced MRI for detecting breast cancer reaches 88%, with a
specificity of 68%. The positive predictive value is reported to be 72%, with a
negative predictive value of 85% (Bluemke et al., 2004). The reported sensitivity
and specificity may vary in different publications due to differences in study
populations, and technical and diagnostic criteria used. Reported sensitivities
therefore vary from 83-100%, with reported specificities varying from 29-100%
(Rausch et al., 2006).